GEM Business Division

Macrogen produces and supplies genetically engineered mice (GEM). A genetically engineered mouse (GEM) is a laboratory mouse that has had certain genes inserted, removed, or modified using gene-editing technologies. Such mice are widely used in biological and medical research to identify the functions of human genes. They are also an essential experimental resource in the preclinical stage of new drug development.

Macrogen’s main GEM service offers transgenic mice and knock-out/knock-in mice. A transgenic mouse is one in which a specific gene has been inserted to study the function of the gene. A knock-out mouse is a genetically engineered mouse in which the expression of a target gene has been suppressed by removing a specific gene, and a knock-in mouse is a genetically engineered mouse in which the expression of a target gene can be adjusted or explored by modifying a certain gene.

Macrogen also offers a wide range of other GEM-related services including mass reproduction, microinjection, mouse line recovery, embryo freezing and reproduction to live, and KO/TG mouse maintenance.

To ensure process efficiency, our genetically engineered mice are produced after a thorough experimental design process with our clients. We provide a customized partial process service to meet various client requirements, and our strict quarantine system ensures all mice are maintained and supplied in a specific pathogen free (SPF) state.

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