Bioinformatics Institute

Bioinformatics Institute, Discovering the Secret of Life Based on Genome Information

The preservation and expression of heredity information is a crucial process that forms the foundation of biological phenomena. The attempt to interpret such biological phenomena theoretically has been pursued for a long time, and now with the accumulation of genetic information, the field of bioinformatics has been established. Although bioinformatics is used in many areas of interpreting biological data, it has gradually developed with a focus on the analysis of genome information.

In particular, with the advent of the genome sequencing, which is known as the Next Generation Sequencing (NGS) techniques, a wide range of biological data and technologies were essential for the efficient analysis of high-throughput data. The rapid advances in development of sequencing technologies and bioinformatics in recent years have enabled an increasing number of applications in biomedical and biological research field. Specially on biomedical research field point of view, it has led to the prevention, diagnosis and treatment of diseases (including cancers) based on individual genetic backgrounds and lifestyles.

Macrogen bioinformatics institute has the key technologies research and development program to process and interpret genome information related to various biological species and it is currently conducting joint research with major research institutes in Korea and overseas.

In 2016, we collaborated with Macrogen Genome Research center and the genomic medicine institute at Seoul National University to publish the Korean Reference Genome Sequence (AK1) in Nature. This achievement recognized as the most perfect human genome sequence aside from human reference genome focusing on Westerners. It has confirmed Macrogen’s capability of genome analysis technique as the world leading pioneer. This has expanded the understanding of the human diploid genome, and is able to discover thousands of Asian-specific genetic structural variations and consequently forming a phased genome.

Based on the research and development experiences accumulated so far, the Bioinformatics Institute of Macrogen will conduct a variety of studies in the field of genome analysis, including the development of advanced algorithms and pipeline.