Superior NGS service with a high level of precision and speed
based on world-class analytical infrastructure
NGS (Next Generation Sequencing) is a method for reading a genome by dividing it into many pieces, assembling the obtained sequence pieces and analyzing the
sequence of the entire genome.
Macrogen is a global leader in precision medicine that is capable of predicting and diagnosing diseases through NGS information-based R&D and collaboration with medical institutions, presenting personalized treatment plans according to genetic characteristics.
There has been rapid progress in technologies related to NGS since its commercialization in 2000, which has produced a large volume of genome information for use in research. Especially since the cost and time for genome analysis gradually decreased, the demand for genome analysis for living organisms including humans has rapidly increased and became available to use in various research. Recently, mostly in the medical field, clinical studies based on NGS are actively conducted and many studies are in progress to identify genetic variance and the functions of new genes. This is expected to speed up the realization of precision medicine that can provide treatments optimized for individual patients based on their genome.
Macrogen produces a large amount of genome information every year using various kinds of equipment, provides quicker and more accurate genome analysis service at an economical price to assist in studies conducted by researchers, and offers a diagnostic service to the public. We provide genome analysis services suitable for research, such as whole genome, exome, transcriptome, epigenome, metagenome, and single cell multi-omics sequencing and bioinformatics results based on the data. Offering a total genomic solution to researchers all over the world based on our extensive experiences and know-how accumulated over the years, Macrogen leads the field of precision medicine by utilizing NGS technology
Whole Genome Sequencing
Whole Genome Sequencing (WGS) is a procedure for reading the entire genome and analyzing related genetic information.
Whole Genome Resequencing
Whole Genome De novo Sequencing
Whole Exome Sequencing
WES (Whole Exome Sequencing) is a procedure for selective analysis in an exon area known to be where genes exist.
Main Capture Kit
As a technique for analyzing RNA obtained from gene expression, it allows checking the difference in expression profile and various mutation information between samples.
mRNA / Total RNA Sequencing
The exact data value can be known through the mRNA expression value identified based on the read. It can be used for research such as novel transcriptome,
fusion gene, alternative splicing, and mutation information as well as inter-gene expression profiles. Recently, studies on gene expression
at the single cell level is also being actively carried out.
Small RNA Sequencing
In addition to mRNA from which genes are transcribed, non-coding RNA that does not contain gene information, especially small RNA, has been found to be key
factors in gene expression control and are actively studied. By analyzing the key types of the small RNA family, miRNA, siRNA, piRNA and snRNA, we can gain insights
into gene expression control and apply them to the development and diagnosis of biomarkers.
For genes composed of exons and introns, new transcripts continue to be discovered by the combination of exon regions that are expressed. Isoform sequencing using a long read platform allows us to identify full-length transcripts that have not been revealed before, so it is gaining attention in regard to functional studies of gene.
Exosomal RNA Sequencing
An exosome is a cell-derived endoplasmic reticulum of less than 200nm, and it contains various types of biomolecules including proteins, DNA, and RNA derived from the origin cell. By using these characteristics, it can be used as a biomarker for diagnosis or for disease monitoring. Recently, the fields of application for treatment, as well as cosmetic applications, are broadening.
This is a technique for determining whether the function of a specific gene is properly expressed by external environmental factors.
WGBS (Whole Genome Bisulfite Sequencing) is a key NGS technique that can check methylation. This DNA processing technique uses sodium bisulfite, a substance that converts unmethylated cytosine to uracil, to observe the level of methylation of DNA by analyzing the nucleotide sequence afterward.
ATAC is a technique used to analyze accessible DNA regions through NGS (Next Generation Sequencing).
Macrogen provides a high level of genetic sequencing data quickly based on its NGS (next generation sequencing) performance, which ranks first in Korea and fifth in the world, and supports personalized sample tests. By assessing the open state of closed chromatin condensed into histone proteins for gene expression, the accessible region of RNA polymerase can be inferred, or the transcription factor binding site and nucleosome (nucleosome) location information can be acquired. In order for the genetic information stored in DNA to actually play a role, it should be expressed as a transcript (RNA). The DNA expression is controlled by changes in the DNA sequence itself, but it can also be regulated by changes in the helix structure or changes in surrounding proteins without changing the DNA sequence. The study of changes in gene function through structural changes or changes in surrounding proteins without changes in the DNA sequence is known as epigenetics.
This is a method for identifying microbial communities in different environments that allows you to check the diversity of species in the environment by sequencing a set of genomes that exist in various environments at once.
Metagenome Amplicon Sequencing
Metagenome Shotgun Sequencing